Every track workstation exposes [Left: SHA-256 Frozen Inputs & Replay CLI] · [Center: Interactive Domain Physics/Clinical SVG Canvas] · [Right: Solver-Free G1–G4 Receipt & MFDS SaMD Dossier].
Upgrades APOSTOLUS v1 phenotype-only baseline (9.18% Top-5, kept intact as ablation) by integrating patient VCF genotype + ClinGen 8,667 expert-curated variants + Tavtigian Bayesian ACMG point scale.
Newly introduced flagship track replacing wet-lab animal regeneration RFP 1-1; solves closed-loop LV/RV time-varying elastance ODEs calibrated against real PhysioNet MIMIC-IV ICU hemodynamics.
Replaces xenotransplantation RFP 2-2; models exact 3D skeletal projection distortion under ±15° limb rotation/flexion via Beer-Lambert ray-casting + real UCI 310-patient orthopedic sagittal alignment cohort.
Replaces autologous CAR-T trial RFP 3-5; directly evaluates real 552 human intrapartum deliveries (PhysioNet CTU-UHB 4 Hz FHR/UC + umbilical arterial pH) and unlocks 95pt synergy with OB/GYN M.D. advisor.
Replaces APOSTOLUS prevent12 textbook risk equations with real 360 Hz binary ambulatory ECG waveform/annotation analysis (PhysioNet MIT-BIH) + motion-artifact electrode impedance abstention.
Replaces Phase I vaccine trial RFP 10-1; pairs West-zone pulmonary shunt & driving-pressure mechanics with real Beth Israel Deaconess ICU stays, labs, and chartevents (MIMIC-IV Demo 2.2).
Replaces animal microbiome RFP 6-1; solves pulsatile bifurcated True/False-Lumen Womersley-Windkessel pressure-flow waves across 360 Stanford Type B tear geometries + MIMIC arterial pulse calibration.
Upgrades APOSTOLUS synth8 onto the EXACT target disease of RFP 11-1 [6-3]: 217 real LTRC IIP/IPF lung transcriptomes (GSE32537) externally validated on independent IPF cohort GSE24206 + DP-TSTR audit.
Replaces synthetic speech cog16 with real Washington Univ. OASIS-2 150-subject / 373-visit longitudinal MRI morphometry (nWBV, eTIV, ASF, CDR) under strict subject-locked splits + ARIA susceptibility physics.
Directly fulfills KHIDI RFP 18-3 p.102 explicit requirement ('virtual clinical simulation environment with ≥95% mismatch detection') across 2,400 multi-modal FHIR/DICOM/consent/anticoagulant faults + Cholec80.
Upgrades APOSTOLUS dispense18 synthetic circles with official ePillID 3,728 consumer-image 5-fold benchmark + multi-pill pouch occlusion/glare abstention + renal/pediatric MFDS DUR rule verification.
Replaces synthetic screen51 grid with real D3R Grand Challenge 4 BACE1 (n=34) & Cathepsin-S (n=39) experimental ΔG/IC50 structures + Zwanzig FEP cycle closure + live CRO-Bridge 4PL/PK audit.